The Science Behind HarmonEyes

Science + AI and Eye-Tracking Data = Innovation

HarmonEyes’ parent company, RightEye, has pushed eye-tracking science into areas previously unexplored with more than 48 published articles in peer-reviewed journals.

Explore our full list of published articles and conference presentations to see how we are leading the research and making the world richer.

August 2024

Eye Movement Differences in Contact Versus Non-Contact Olympic Athletes

The purpose of this study was to investigate the difference in oculomotor functioning between Olympic-level contact and non-contact sports participants. In total, 67 male and female Olympic-level contact (n=27) and non-contact (n=40) athletes completed oculomotor tasks, including Horizontal Saccade (HS), Circular Smooth Pursuit (CSP), Horizontal Smooth Pursuit (HSP), and Vertical Smooth Pursuit (VSP) using a remote eye tracker.

Author(s)

Nicholas P. Murray, Melissa Hunfalvay, Christopher Mesagno, BrittanyTrotter, Eva V. Monsma, Ethan Greenstein & Frederick Robert Carrick

Publication

Journal of Motor Behavior

July 2024

Age-Based Developmental Biomarkers in Eye Movements: A Retrospective Analysis Using Machine Learning

This study aimed to identify when and how eye movements change across the human lifespan to benchmark developmental biomarkers. The sample size comprised 45,696 participants, ranging in age from 6 to 80 years old (M = 30.39; SD = 17.46). Participants completed six eye movement tests: Circular Smooth Pursuit, Horizontal Smooth Pursuit, Vertical Smooth Pursuit, Horizontal Saccades, Vertical Saccades, and Fixation Stability. These tests examined all four major eye movements (fixations, saccades, pursuits, and vergence) using 89 eye-tracking algorithms.

Author(s)

Melissa Hunfalvay, Takumi Bolte, Abhishek Singh, Ethan Greenstein, Nicholas P. Murray and Frederick Robert Carrick

Publication

Brain Sciences

January 2024

Reliability and Validity of a 9-Point Ocular Alignment Test of Cardinal Gaze using Eye Tracking

The purpose of this study is to determine the reliability of eye-tracking enabled 9-Point Motor Function Test and to determine the validity of the eye-tracking system compared with a traditional Cover Test (CT). Fifty participants between the ages of 19-61 years were tested by a veteran Board-Certified Optometrist using the RightEye 9-Point Motor Function Test (MFT; eye tracking test) and a Cover Test. Participants completed both the 9-Point MFT and the Cover Test in random order and completed the 9-Point MFT test twice to assess test-retest reliability. Reliability was evaluated using Cronbach’s Alpha (CA). Overall reliability was acceptable to excellent per statistical standards.

Author(s)

Melissa Hunfalvay, PhD, Kenneth Kopolow, OD & Nicholas P. Murray, PhD

Publication

Vision Development & Rehabilitation

December 2023

Automated Eye Tracking Enables Saccade Performance Evaluation of Patients with Concussion History

Automated eye tracking could be used to evaluate saccade performance of patients with concussion history, providing quantitative insights about the degree of oculomotor impairment and potential vision rehabilitation strategies for this patient population. The purpose of this study is to evaluate the saccade performance of patients with concussion history based on automated eye-tracking test results.

Author(s)

Ailin Song, MD, MHSc, Rami Gabriel, MD, Omar Mohiuddin, MS, MPH, Diane Whitaker, OD, C. Ellis Wisely, MD, MBA, and Terry Kim, MD

Publication

Optometry and Vision Science

July 2022

THE EFFECTS OF CHIROPRACTIC CRANIOPATHY UPON TBI PATIENTS MEASURED BY EYE SACCADES

Saccades appear to be a reliable measure of brain dysfunction following Traumatic Brain Injury (TBI). Four subjects were chosen at random having a history of traumatic brain injury and active symptomatology. Trauma and chronic stresses are potentially associated with certain distortion patterns of the pelvis and cranium in the Sacro Occipital Technic® Methods (SOT™) of chiropractic and Chiropractic Craniopathy.

Author(s)

Unger, Joseph F Jr., DC1,2

Publication

Logan University, Atrium Health Services

May 2022

Long-Term Effects of Low-Level Blast Exposure and High-Caliber Weapons Use in Military Special Operators

Chronic low-level blast exposure has been linked with neurological alterations and traumatic brain injury (TBI) biomarkers. Impaired smooth-pursuit eye movements (SPEM) are often associated with TBI. The purpose of this study was to determine whether long-term operators of low-level blast exposure or high-caliber weapons use displayed oculomotor behaviors that differed from controls.

Author(s)

Hunfalvay, Murray, Creel and Carrick

Publication

Brain Science

March 2022

Developing Brain in Danger: Critical Periods of Vulnerability from In-utero to Adolescence

The perinatal temporal window is a highly vulnerable time in which environmental factors, such as nutrients, drugs, infections, chemicals, and stress, experienced by the mother can be communicated to the offspring and produce lasting consequences on the newborn brain. Eye tracking is a non-invasive method used to understand these changes.

Author(s)

Cannizzaro, Melis, and Laye

Publication

Frontiers in Neuroscience; Frontiers in Genetics; Frontiers in Behavioral Neuroscience

March 2022

Alpha Desynchronization Increases During Dynamic Visual Assessments Within One Year of Mild Traumatic Brain Injury

Mild Traumatic Brain Injuries (mTBI) can lead to visual processing deficits, including decreased visual acuity, visual field impairment, eye movement dysfunction- including vergence, saccadic, smooth pursuit movements, and an increase in mental workload during visual tasks. The purpose of this project was to examine the relationship between brain activity and visual-motor deficit in participants with a recent mTBI compared to healthy controls.

Author(s)

Warlick, Lawton, Breitbach, Hunfalvay, Murray

Publication

National Science Foundation: Biomedical Engineering in Simulations, Imaging, and Modeling (BME-SIM)

February 2022

Eye-Tracker Outcomes from Static, Mobile, Virtual Reality Eye-Tracking Devices

This volume explores the latest eye-tracking methodologies that help researchers understand the background, methods, and applications involved in these studies.

Author(s)

Murray, N. P., Trotter, B. M., Sandri Heidner, G., Herman, C., & Hunfalvay, M.

Publication

Book, Springer US

December 2021

Oculomotor Behavior Predict Professional Cricket Batting and Bowling Performance

The purpose of this project is to determine if a series of oculomotor measures can predict batting and bowling performance in professional cricket players.

Author(s)

Murray, Lawton, Rider, Harris and Hunfalvay

Publication

Frontiers in Human Neuroscience

December 2021

Smooth Pursuit Eye Movements as a Biomarker for Mild Concussion within 7-Days of Injury

Deficits in smooth-pursuit eye movements (SPEM) are often associated with mild traumatic brain injury (TBI). Eye tracking tests serve as a quick objective clinical tool to assess such predictive visual tracking. In this study, SPEM was assessed along circular, horizontal and vertical trajectories in adolescents with concussion and age-matched controls.

Author(s)

Hunfalvay, Murray, Mani & Carrick

Publication

Brain Injury

October 2021

The Pupillary Light Reflex as a Biomarker of Concussion

A retrospective clinical review of pupillary light reflex. Results show differences in age, gender and concussion status.

Author(s)

Carrick, Azzolino, Hunfalvay, Pagnacco, Oggero, Arcy, Adbulrahman, Sugaya

Publication

Life

September 2021

Visual Performance as a Function of Clear Central Aperture Diameter with a Defocused Myopic Periphery

The purpose of this study was to assess the effect of clear central apertures of different diameters with a defocused retinal periphery, using a range of visual performance tasks. The finding has important applications for spectacle and contact lens designs to optimize myopia.

Author(s)

Kubota, Joshi, Samandarova, Oliva, Selenow, Gupta, Ali, Ciuffreda

Publication

Optometry and Visual Science

August 2021

Brain Vital Signs in Elite Ice Hockey: Towards Characterizing Objective and Specific Neurophysiological Reference Values for Concussion Management

Provides practical clinical implementations that overcome inherent challenges related to dependence on a baseline. This article establishes normative reference data sets.

Author(s)

Carrick, Pagnacco, Azzolino, Hunfalvay, Oggero, Frizzell, Smith, Pawlowski, Campbell, Fickling, Lakhani, Arcy

Publication

Frontiers in Neuroscience

July 2021

[Presenting October 2021] Circular Smooth Pursuit Assessment and Neuronal Activity in the Alpha Frequency as Predictors of mTBI

Combination of circular smooth pursuit assessment and neuronal activity in the alpha frequency have the potential to be a successful diagnostic tool for TBIs.

Author(s)

Breitbach, Lawton, Warlick, Hunfalvay, Murray

Publication

Biomedical Engineering Society. National Science Foundation.

May 2021

Oculomotor Training for Poor Saccades Improves Functional Vision Scores and Neurobehavioral Symptoms

Examines oculomotor training exercises for poor saccadic eye movements. Includes neurobehavioral symptoms pre and post-treatment.

Author(s)

Hunfalvay, Murray, Tyagi, Whittaker, Noel

Publication

American Congress of Rehabilitation Medicine

March 2021

Classification of Comprehensive Neuro-Ophthalmologic Measures of Postacute Concussion

Compares persons with and without concussion after the acute injury period. Classification accuracy of clinically important discriminator eye-tracking (ET) metrics. 6 eye-tracking measures that reflect slowed visual reaction time had a combined sensitivity of 77.8% and specificity of 92.6% for discriminating between the groups

Author(s)

Feller, Goldenberg, Asselin, Merchant-Borna, Abar, Jones, Mannix, Kawata, Bazarian

Publication

Journal of the American Medical Association: Neurology

December 2020

Fixation Stability as a Biomarker for Differentiating Mild Traumatic Brain Injury from Age Matched Controls in Pediatrics

Examines fixation stability in pediatric patients with mTBI versus age-matched controls.

Author(s)

Hunfalvay, Murray, Carrick

Publication

Brain Injury

December 2020

Head Position and Posturography: A Novel Biomarker to Identify Concussion Sufferers

Head and neck position induced by statically maintained head turns is associated with lower stability scores than the standardized head neutral position of the mCTSIB in Post-Concussion Syndrome (PCS) subjects but not in healthy controls. Head positions of the neutral plane provide biomarkers that differentiate subjects suffering from PCS from healthy normal subjects.

Author(s)

Carrick, Pagnacco, Hunfalvay, Azzolino, Oggero

Publication

Brain Sciences

November 2020

Oculomotor Behavior as a Biomarker for Differentiating Pediatric Patients With Mild Traumatic Brain Injury and Age Matched Controls.

Explains how the combined measurement of saccades, smooth pursuit, fixations, and reaction time represent a biomarker for differentiating pediatric patients with mild traumatic brain injury compared to age-matched controls.

Author(s)

Hunfalvay, Murray, Roberts, Tyagi, Barclay, Carrick

Publication

Frontiers in Behavioral Neuroscience

June 2020

Visual and Oculomotor Abilities Predict Professional Baseball Batting Performance

RightEye tests predict discipline at the plate for Major League Baseball athletes.

Author(s)

Liu, Edmunds, Burris & Appelbaum

Publication

International Journal of Performance Analysis in Sport

May 2020

A Comparison of Cardinal Gaze Speed Between Major League Baseball Players, Amateur Prospects, and Nonathletes

Shows differences between Major League Baseball, amateur prospects, and non-athletes in visual speed of gaze.

Author(s)

Kubitz, Roberts, Hunfalvay, Murray

Publication

Journal of Sports and Performance Vision

January 2020

Vertical Smooth Pursuit as a Diagnostic Marker of TBI

Examines vertical smooth pursuit test to screen patients with mTBI compared with age-matched controls.

Author(s)

Hunfalvay, Barclay, Kelly, Roberts, Murray, Tyagi, Carrick

Publication

Concussion

October 2019

Visual Assessments Predict Swing Propensity in Professional Baseball

[Conference Presentation] Shows how better visual abilities predict O-Swing and Z-Swing propensity.

Author(s)

Edmunds, Liu, Appelbaum

Publication

American Academy of Optometry (AAO)

September 2019

Oculomotor Behavior of Acutely Concussed Patients undergoing Hyperbaric Oxygen Treatment & Posters

[Conference Presentation] New eye-tracking technology, such as RightEye, offers an objective, reliable and quantifiable way of differentiating between individuals with different severities of TBI, and those without a TBI.

Author(s)

Hunfalvay, Murray, Tyagi, Denham, Biberdorf, Wegge

Publication

Neuro Optometric Rehabilitation Association (NORA)

July 2019

Horizontal and Vertical Self-Paced Saccades as a Diagnostic Marker of Traumatic Brain Injury

Examines using eye-tracking tests to measure horizontal and vertical saccades as a marker of damage to neural circuits associated with TBI.

Author(s)

Hunfalvay, Roberts, Murray, Tyagi, Kelly, Bolte

Publication

Concussion

June 2019

An Examination of the Oculomotor Behavior Metrics Within a Suite of Digitized Eye Tracking Tests

[Conference Presentation] The purpose of this study was to examine the reliability of oculomotor behavior metrics in healthy individuals, to determine the normative values through cluster analysis, and to compare oculomotor behavior metrics by age groups in a suite of digitized eye-tracking tests.

Author(s)

Bolte, Kubitz, Roberts, Hunfalvay, Tyagi, Murray

Publication

North American Society for the Psychology of Sport and Physical Activity

February 2019

A Comparison of Visual Speed to the Cardinal Gaze Positions Between Major League Baseball Players and Amateur Prospects

[Conference Presentation] Major League Baseball players have faster eye movements in down and horizontal gaze directions compared with amateur prospects. There are not differences in upward gaze.

Author(s)

Kubitz, Roberts, Hunfalvay, Murray

Publication

North American Society for the Psychology of Sport and Physical Activity

February 2019

An Examination of the Oculomotor Behavior Metrics Within a Suite of Digitized Eye Tracking Tests

This article discusses reliability and normative data across many of the RightEye tests.

Author(s)

Murray, Kubitz, Roberts, Hunfalvay, Bolte, Tyagi

Publication

Vision Development and Rehabilitation (COVD)

October 2018

The Effect of Prior Tennis Experience on Wheelchair Tennis Players’ Visual Search

Examination if prior biped tennis playing experience results in different visual search strategies for wheelchair tennis athletes.

Author(s)

Hunfalvay, Murray

Publication

Adapted Physical Activity Quarterly

August 2018

Interpupillary Distance and Pupil Diameter of Baseball Athletes and Non-Athletes

Examines if differences occur in Interpupillary Distance (IPD) and Pupil Diameter (PD) between professional baseball players and non-athletes.

Author(s)

Hunfalvay, Kubitz, Murray, Tibbert, Bolte

Publication

Optometry and Visual Performance

July 2018

Reliability of Computerized Eye-tracking Reaction Time Tests in Non-athletes, Athletes, and Individuals with Traumatic Brain Injury

Examination of visual and motor reaction time in athletes, non-athletes, and those with concussion.

Author(s)

Lange, Hunfalvay, Murray, Roberts, Bolte

Publication

Optometry and Visual Performance

March 2018

Brain Monitoring Devices in Neuroscience Clinical Research: The Potential of Remote Monitoring Using Sensors, Wearables, and Mobile Devices

RightEye technology cited in providing reliable estimates of eye-tracking parameters.

Author(s)

Byrom, McCarthy, Scheueler, Muehlhausen

Publication

Clinical Pharmacology & Therapeutics

February 2018

Eye Tracking Technology for Clinical Practice: Benefits, Limitations, and Considerations

This opinion piece discusses the use of eye-tracking in clinical practice, including benefits of such technology.

Author(s)

Hunfalvay

Publication

Optometry and Visual Performance

January 2018

Applied Psychophysiology: Using Biofeedback, Neurofeedback, and Visual Feedback

Visual assessment benefits and tools using eye-tracking in performance (textbook chapter).

Author(s)

Smith, Hunfalvay, Herzog, Beauchamp

Publication

Assessment in Applied Sport Psychology

December 2017

An Exploration of Shifts in Visual Fixation Prior to the Execution of Baseball Batting: Evidence for Oculomotor Warm Up, Attentional Processes or Pre-Performance Routines?

Results suggest that athletes exhibit multiple dynamic shifts in visual fixation prior to the onset of pitcher’s action. A significant positive relationship was found between the number of shifts in visual fixations and batting average.

Author(s)

Hunfalvay, Roberts, Ryan, Murray, Tabano, Martin

Publication

International Journal of Sport Sciences

July 2017

The Reliability, Validity, and Normative Data of Interpupilary Distance and Pupil Diameter Using Eye-Tracking Technology

The purpose of this study was to determine the reliability of interpupillary distance (IPD) and pupil diameter (PD) measures using an infrared eye tracker and central point stimuli.

Author(s)

Murray, Hunfalvay, Bolte

Publication

Translational Vision Science and Technology

June 2017

Lingering Binocular Vision Issues after a Suspected Concussion: A Case Study

This case study examines clinical assessments and eye tracking to monitor patient change over time after extensive vision therapy from a suspected concussion.

Author(s)

Hunfalvay

Publication

Translational Biomedicine

April 2017

Evaluation of Stereo Acuity in Professional Baseball and LPGA Athletes Compared to Non-Athletes

RightEye fine depth perception tests demonstrate reliability and validity. Differences are found between athletes and non-athletes.

Author(s)

Hunfalvay, Orr, Murray, Roberts

Publication

Vision Development and Rehabilitation (COVD)

April 2017

Reliability and Normative Data of Computerized Dynamic Visual Acuity Tests

RightEye DVA tests demonstrate strong reliability results

Author(s)

Murray, Hunfalvay, Roberts, Lange

Publication

Vision Development and Rehabilitation (COVD)

December 2016

Home-Based Therapy for Symptomatic Convergence Insufficiency in Children: A Randomized Clinical Trial

To compare the effectiveness of home-based (HB) computer vergence/accommodative therapy (HB-C) to HB near target push-up therapy (HB-PU) and to HB placebo treatment (HB-P) among children aged 9 to G18 years with symptomatic convergence insufficiency (CI).

Author(s)

Pediatric Eye Disease Investigator Group

Publication

Optometry and Vision Science

June 2016

Wearing Eye Tracking Technology during Batting Practice: Assessing the Experiences of Professional Baseball Athletes

Examines the use of eye-tracking technology in practice and reaction of the technology by athletes.

Author(s)

Roberts, Tabano, Hunfalvay

Publication

International Journal of Sports Science

March 2016

A Comparison of Visual Search Strategies of Elite and Non-Elite Tennis Players Through Cluster Analysis

Eye-tracking research used to assess levels of performance with novel statistical analysis.

Author(s)

Murray, Hunfalvay

Publication

Journal of Sports Sciences

October 2015

Treatment of symptomatic convergence insufficiency with home-based computerized vergence system therapy in children

To evaluate the efficacy of a home-based computer orthoptic program for symptomatic convergence insufficiency (CI) in children.

Author(s)

Huston, Hoover

Publication

Journal of AAPOS

November 2012

Convergence insufficiency–A Major Review

Convergence insufficiency is a common binocular vision disorder affecting approximately 5% of the population in the United States. It is often associated with a host of symptoms that occur when doing near work, such as reading and computer viewing. This article reviews the existing literature on convergence insufficiency including etiology, diagnosis, sensorimotor findings, and management.

Author(s)

Cooper, Jamal

Publication

American Optometric Association

March 2011

Treatment of symptomatic convergence insufficiency with a home-based computer orthoptic exercise program

To determine the efficacy of a home-based computer orthoptic program to treat symptomatic convergence insufficiency

Author(s)

Serna, Rogers, McGregor, Golden, Bremer, Rogers

Publication

Journal of AAPOS

December 2009

Reduction of Symptoms in Binocular Anomalies Using Computerized Home Therapy HTS

Recent studies have found that symptoms associated with convergence insufficiency are reduced by in-office vision therapy with supplemental home therapy. This retrospective study was designed to evaluate the changes in symptoms using an automated, home computer vision therapy program (HTSTM) in accommodative/vergence disorders.

Author(s)

Cooper, Feldman

Publication

Optometry

December 2007

Computerized Vision Therapy for Home and Office Treatment of Accommodative & Vergence Disorders & Amblypia

Vision therapy or orthoptics is the standard treatment for symptomatic accommodative-vergence anomalies and amblyopia. Computerization of vision therapy has improved treatment results by: standardizing protocols; providing positive or negative reinforcement based upon responses; eliminating experimental (therapist) bias in research and/or therapy; and standardizing stimuli and methodology for diagnosis/treatment.

Author(s)

Cooper

Publication

Journal of Behavioral Optometry

July 2007

The Role of Verbal Cues in Visual Search Behavior During Observational Llearning

Connects verbal cues with visual cues during observational learning.

Author(s)

Coker & Hunfalvay

Publication

Journal of Sport & Exercise Psychology

March 2005

Characteristics of Expert Wheelchair Tennis Players According to Visual Selectie Attention Preference

Examines the visual search patterns of wheelchair tennis players related to past experience.

Author(s)

Hunfalvay

Publication

Research Quarterly for Exercise and Sport

December 2003

Validity & Reliability of the Revised Convergence Insufficiency Symptoms Survey in Children Aged 9 to 18 Years

To assess the validity and reliability of the Convergence Insufficiency Symptom Survey (CISS) in children aged 9 to 18 years. The CISS is the primary outcome measure for a pilot study evaluating two different treatments for convergence insufficiency (CI).

Author(s)

Borsting, Rouse, Mitchell, Scheiman, Cotter, Cooper, Kulp, London, Convergence Insufficiency Treatment Trial Group

Publication

Optometry and Vision Science

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